New diabetes drugs may better prevent dementia than metformin

New Diabetes Drugs May Better Prevent Dementia Than Metformin

A new large study suggests that GLP-1 receptor agonists may be better than metformin at protecting the brain and lowering the risk of dementia in people with type 2 diabetes.

This research, published in BMJ Open Diabetes Research & Care, compared the effects of GLP-1 drugs and metformin on the brain. Both are commonly used to manage blood sugar in type 2 diabetes and have been shown to potentially protect the brain.

Researchers analyzed the health records of over 174,000 people with type 2 diabetes, with half taking GLP-1 drugs and the other half taking metformin, for at least six months. The results showed that about 2.5% of people taking GLP-1 drugs developed dementia, compared to nearly 5% of those on metformin.

GLP-1 receptor agonists may lower the risk of dementia in people with type 2 diabetes.

Author's summary: New diabetes medications may prevent dementia better than metformin.

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Knowridge Science Report Knowridge Science Report — 2025-10-18

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